Hemoglobin adducts in rats chronically exposed to room-aged cigarette sidestream smoke and diesel engine exhaust

Adv Exp Med Biol. 2001;500:153-6. doi: 10.1007/978-1-4615-0667-6_20.

Abstract

Under controlled conditions with exaggerated concentrations of environmental aerosols, the biologically effective dose markers suggested in the literature as being specific for ETS (i.e., HPB Hb adducts for TSNA exposure) and DEE (i.e., l-aminopyrene Hb adducts for l-nitropyrene exposure) did not respond. A slight but dose-dependent increase in 4-ABP Hb adduct levels was seen in RASS-exposed rats.

MeSH terms

  • Animals
  • Automobiles
  • Female
  • Gasoline / adverse effects*
  • Hemoglobins / metabolism*
  • Male
  • Protein Denaturation*
  • Rats
  • Rats, Wistar
  • Tobacco Smoke Pollution / adverse effects*
  • Vehicle Emissions

Substances

  • Gasoline
  • Hemoglobins
  • Tobacco Smoke Pollution
  • Vehicle Emissions