Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions

Adv Exp Med Biol. 2001:500:635-8. doi: 10.1007/978-1-4615-0667-6_95.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aniline Compounds / administration & dosage
  • Aniline Compounds / metabolism
  • Animals
  • Anticarcinogenic Agents / administration & dosage
  • Anticarcinogenic Agents / metabolism*
  • Cytochrome P-450 CYP1A1 / metabolism*
  • Down-Regulation*
  • Drug Interactions
  • Enzyme Induction
  • Indoles / administration & dosage
  • Indoles / metabolism*
  • Liver / drug effects
  • Liver / enzymology
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Nicotine / administration & dosage
  • Nicotine / metabolism
  • Oxygenases / metabolism*
  • Rats
  • Rats, Inbred F344
  • Tamoxifen / administration & dosage
  • Tamoxifen / metabolism

Substances

  • Aniline Compounds
  • Anticarcinogenic Agents
  • Indoles
  • Tamoxifen
  • Nicotine
  • N,N-dimethylaniline
  • indole-3-carbinol
  • Oxygenases
  • dimethylaniline monooxygenase (N-oxide forming)
  • Cytochrome P-450 CYP1A1
  • 3,3'-diindolylmethane