Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry

Adv Exp Med Biol. 2001;500:663-73. doi: 10.1007/978-1-4615-0667-6_99.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetaminophen / administration & dosage
  • Acetaminophen / metabolism*
  • Acetanilides / administration & dosage
  • Acetanilides / metabolism*
  • Analgesics, Non-Narcotic / administration & dosage
  • Analgesics, Non-Narcotic / metabolism*
  • Animals
  • Autoradiography
  • Electrophoresis, Gel, Two-Dimensional / methods
  • Liver / metabolism*
  • Mass Spectrometry
  • Mice
  • Mice, Inbred C57BL
  • Proteins / metabolism*

Substances

  • Acetanilides
  • Analgesics, Non-Narcotic
  • Proteins
  • Acetaminophen
  • 3-hydroxyacetanilide