Ebola Virus: The Search for Vaccines and Treatments

Cell Mol Life Sci. 2001 Nov;58(12-13):1826-41. doi: 10.1007/PL00000821.

Abstract

Ebola viruses belong to the family Filoviridae, which are among the most virulent infectious agents known. These viruses cause acute, and frequently fatal, hemorrhagic fever in humans and nonhuman primates. Currently, no vaccines or treatments are available for human use. This review describes Ebola viruses, with a particular focus on the status of research efforts to develop vaccines and therapeutics and to identify the immune mechanisms of protection.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Viral / immunology
  • Antiviral Agents / therapeutic use
  • Cytokines / metabolism
  • Disease Models, Animal
  • Ebolavirus / drug effects
  • Ebolavirus / genetics
  • Ebolavirus / immunology*
  • Ebolavirus / pathogenicity
  • Ebolavirus / physiology*
  • Genes, Viral
  • Hemorrhagic Fever, Ebola / epidemiology
  • Hemorrhagic Fever, Ebola / physiopathology
  • Hemorrhagic Fever, Ebola / prevention & control
  • Hemorrhagic Fever, Ebola / therapy*
  • Humans
  • T-Lymphocytes, Cytotoxic / immunology
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
  • Viral Vaccines* / immunology
  • Viral Vaccines* / therapeutic use

Substances

  • Antibodies, Viral
  • Antiviral Agents
  • Cytokines
  • Viral Proteins
  • Viral Vaccines