Development of IgE and allergy in infancy

J Allergy Clin Immunol. 1975 Oct;56(4):296-307. doi: 10.1016/0091-6749(75)90104-9.


Serum IgE levels were followed throughout the first year of life in a sample of 34 infants from atopic and nonatopic families. Their parents' serum IgE levels were also measured. Neonatal levels ranged from 0 to 10 U/ml. Half of the study group, which included a high proportion of infants from atopic families, maintained serum IgE levels below 10 U/ml until 1 yr of age. In the remainder, the serum IgE exceeded 10 U/ml before 1 yr of age, but the time of increase and the rate of increase varied from infant to infant; the sooner the IgE started to increase, the higher was the serum IgE level at 1 yr of age. The relationship of serum IgE level to the development of atopic disease and to other parameters was analyzed. Elevation of serum IgE level at or before 1 yr of age was highly correlated with atopic disease in the first 2 yr of life. The elevation preceded the manifestation of atopy.

MeSH terms

  • Aging
  • Asthma / diagnosis
  • Eczema / diagnosis
  • Female
  • Humans
  • Hypersensitivity, Immediate / diagnosis
  • Hypersensitivity, Immediate / immunology*
  • Immunoglobulin A / analysis
  • Immunoglobulin E / analysis*
  • Infant
  • Infant, Newborn
  • Male
  • Parents
  • Radioimmunoassay
  • Respiratory Tract Infections
  • Rhinitis, Allergic, Seasonal / diagnosis


  • Immunoglobulin A
  • Immunoglobulin E