August 2001: Sellar/suprasellar mass in a 59-year-old woman

Brain Pathol. 2002 Jan;12(1):135-6, 139.

Abstract

The August 2001 COM. Symptomatic granular cell tumors (GCTs) of the neurohypophysis are rare lesions. They are generally regarded as benign neoplasms, although detailed descriptions of the natural course of the tumors are limited to a few cases. We report on a 59-year-old woman with a large GCT of the neurohypophysis and rapid onset of symptoms. Although lacking definitive signs of malignancy, the tumor showed nuclear polymorphism, proliferative activity, evidence of a mutation of the tumor suppressor gene p53 as well as expression of the apoptosis-inhibiting protein bcl-2. These indices may be useful in defining more precisely the clinicopathological prognosis for neurohypophyseal GCTs.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Female
  • Granular Cell Tumor / pathology*
  • Granular Cell Tumor / physiopathology
  • Headache / etiology
  • Headache / pathology
  • Headache / physiopathology
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / physiopathology
  • Optic Chiasm / pathology*
  • Optic Chiasm / physiopathology
  • Optic Nerve Neoplasms / secondary*
  • Pituitary Diseases / pathology*
  • Pituitary Diseases / physiopathology
  • Pituitary Gland, Posterior / pathology*
  • Pituitary Gland, Posterior / physiopathology
  • Pituitary Gland, Posterior / ultrastructure
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / physiopathology
  • Sella Turcica / pathology*
  • Treatment Outcome
  • Vision, Low / etiology
  • Vision, Low / pathology
  • Vision, Low / physiopathology
  • Vomiting / etiology
  • Vomiting / pathology
  • Vomiting / physiopathology

Substances

  • Biomarkers, Tumor