Japanese generalised osteoarthritis was associated with HLA class I--a study of HLA-A, B, Cw, DQ, DR in 72 patients

Clin Rheumatol. 2001;20(6):417-9. doi: 10.1007/s100670170006.


To investigate the association between generalised osteoarthritis (GOA) and HLA-A, B, Cw, DQ and DR, we typed for HLA in 72 Japanese patients with GOA and compared with those of 1480 normal controls. The antigen frequency of HLA-Cw4 was significantly higher in the GOA group than in the control group. That of B62 was higher, but only uncorrected P values were significant. Those of HLA-Cw1 and Cw10 were significantly lower in the GOA group than in the control group. The antigen frequencies of HLA-DRB1*0101, *0401, *0405, *1001, and *1402, which were reported to be associated with rheumatoid arthritis, in the GOA group were not significantly different from those in the control group. The present study provides evidence of a significant association between Japanese GOA and HLA, which is different from that of Japanese RA. This may suggest that an immunological reaction that is different from RA plays a role in the pathogenesis of GOA.

MeSH terms

  • Aged
  • Alleles
  • Female
  • Genetic Predisposition to Disease / genetics
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-C Antigens / genetics*
  • HLA-DQ Antigens / genetics*
  • HLA-DR Antigens / genetics*
  • Humans
  • Japan
  • Male
  • Osteoarthritis / genetics*
  • Osteoarthritis / immunology*


  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens
  • HLA-C*04 antigen
  • HLA-DQ Antigens
  • HLA-DR Antigens