Intrahepatic recurrences of hepatocellular carcinoma after hepatectomy: analysis based on tumor hemodynamics

Arch Surg. 2002 Jan;137(1):94-9. doi: 10.1001/archsurg.137.1.94.


Hypothesis: Surgical margin, i.e., the area of possible local intrahepatic metastasis, is controversial in hepatectomy for hepatocellular carcinoma.

Design: The blood drainage area of tumor was identified preoperatively by abdominal helical computed tomographic scan under hepatic arteriography and excised as surgical margin. The specimens were pathologically examined on the basis of the corresponding computed tomographic images.

Setting: University hospital.

Patients: From June 2, 1997, to April 24, 2000, 67 patients with hepatocellular carcinoma who underwent curative hepatic resection.

Main outcome measure: Intrahepatic recurrence.

Results: Blood drainage area of tumor could be classified into the following types. The marginal type (drainage into the peritumorous area) was frequent (50 cases) and excised mostly by nonanatomic, limited resection. Portal vein type (drainage into the portal branches) was less common (12 cases) and resected mostly by anatomically systematic hepatectomy. The remaining 5 cases were of the hypovascular type and underwent limited resection. Multiple nodules were frequently found inside the drainage area (4 of 8 cases) and were moderate or poorly differentiated hepatocellular carcinoma, consistent with intrahepatic metastasis. Solitary nodules were mostly outside the drainage area (11 of 12 cases) and contained well-differentiated hepatocellular carcinoma (7 of 10 cases), suggesting multicentric carcinogenesis. Intrahepatic recurrences were commonly found in bilateral or contralateral lobes (17 of 19 cases) and divided into 2 groups with a few (< or =4) and multiple (> or =8) recurrent nodules.

Conclusions: Surgical margin varied according to tumor hemodynamics. Tumor recurrences may result not only from multicentric carcinogenesis but also from intrahepatic metastasis via systemic circulation.

MeSH terms

  • Adult
  • Angiography
  • Carcinoma, Hepatocellular / diagnostic imaging
  • Carcinoma, Hepatocellular / physiopathology*
  • Carcinoma, Hepatocellular / surgery*
  • Female
  • Hepatectomy*
  • Humans
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / physiopathology*
  • Liver Neoplasms / surgery*
  • Male
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / physiopathology*
  • Prospective Studies
  • Regional Blood Flow / physiology
  • Tomography, X-Ray Computed