Reducing capsular thickness and enhancing angiogenesis around implant drug release systems

J Control Release. 2002 Jan 17;78(1-3):211-8. doi: 10.1016/s0168-3659(01)00502-8.


Biological encapsulation and the foreign body reaction can impair the performance of implanted drug release devices. In this article, the classic definition of biocompatibility is questioned. Examples are presented of biomaterials showing unique healing behavior. A new paradigm for biomaterials healing is proposed in which non-specific protein adsorption is inhibited and matricellular proteins are controlled at the surfaces of implants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials*
  • Drug Delivery Systems*
  • Drug Implants*
  • Foreign-Body Reaction
  • Humans
  • Neovascularization, Physiologic*
  • Osteonectin / physiology
  • Osteopontin
  • Sialoglycoproteins / physiology
  • Thrombospondins / physiology


  • Biocompatible Materials
  • Drug Implants
  • Osteonectin
  • SPP1 protein, human
  • Sialoglycoproteins
  • Thrombospondins
  • thrombospondin 2
  • Osteopontin