Association of candidemia and retinopathy of prematurity in very low birthweight infants

Ophthalmology. 2002 Jan;109(1):80-4. doi: 10.1016/s0161-6420(01)00841-7.


Objective: To determine if the presence of candidemia in infants is associated with an increased incidence of threshold retinopathy of prematurity (ROP).

Design: Retrospective, case-controlled study.

Participants and controls: Forty-six infants admitted to the Texas Children's Hospital Neonatal Intensive Care Unit between 1989 and 1999 with a birth weight 1500 g or less, estimated gestational age (EGA) 28 weeks or less, and in whom candidemia developed were matched to a control group of 46 infants based on corresponding birth weight, EGA, and year of birth.

Methods: Records of each infant were reviewed to determine the presence and severity of ROP.

Main outcome measures: Development of threshold ROP, including retinal detachment.

Results: Forty-three infants (93.5%) with candidemia and 39 (84.8%) without candidemia had ROP. Twenty-four infants (52.2%) with candidemia reached threshold and required surgical intervention, compared with 11 infants (23.9%) without candidemia (adjusted odds ratio [OR], 7.4; 95% confidence interval [CI], 1.7-32.1; P = 0.008). Retinal detachment developed in 10 of 24 candidemic infants (41.7%) who reached threshold ROP, compared with 2 of 11 infants (18.2%) without candidemia (OR, 4.4; 95% CI, 0.73-26.9; P = 0.1).

Conclusions: Candidemia is associated with increased risk of threshold ROP. Infants with Candida sepsis should be monitored closely for the development of ROP and progression after treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candidiasis / complications*
  • Case-Control Studies
  • Eye Infections, Fungal / etiology*
  • Female
  • Fungemia / complications*
  • Gestational Age
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Premature
  • Infant, Very Low Birth Weight*
  • Laser Coagulation
  • Male
  • Retinal Detachment / microbiology
  • Retinal Detachment / surgery
  • Retinopathy of Prematurity / microbiology*
  • Retrospective Studies
  • Risk Factors