Cost-effectiveness analysis of applying the Cholesterol and Recurrent Events (CARE) study protocol in Hong Kong

Hong Kong Med J. 2001 Dec;7(4):360-8.


Objective: To determine the cost-effectiveness of secondary prevention with pravastatin in Hong Kong patients with coronary heart disease and average cholesterol levels.

Design: Cost-effectiveness analysis based on published results of the CARE study.

Patients: Men and women post-myocardial infarction with average cholesterol levels.

Main outcome measures: Cost-effectiveness analysis: cost per life saved, cost per fatal or non-fatal coronary event prevented, cost per procedure prevented, and cost per fatal or non-fatal stroke prevented. Cost-utility analysis: gross cost and net cost per quality-adjusted life year gained calculated using two alternative models.

Results: Cost per life saved or death prevented was HK$4,442,350 (non-discounted); cost per fatal or non-fatal cardiac event prevented HK$1,146,413; cost per procedure prevented HK$732,759; and cost per fatal or non-fatal stroke prevented HK$2,961,566. Net cost per quality adjusted life year gained was HK$73,218 and HK$65,280 non-discounted, respectively using the two alternative models.

Conclusions: The results of this study can assist in prioritising the use of health care resources in Hong Kong but should be considered alongside the benefits and costs of alternative interventions for coronary heart disease.

MeSH terms

  • Adult
  • Aged
  • Clinical Protocols
  • Cohort Studies
  • Cost-Benefit Analysis
  • Female
  • Health Care Costs*
  • Hong Kong
  • Humans
  • Hypercholesterolemia / drug therapy
  • Hypercholesterolemia / economics*
  • Hypercholesterolemia / prevention & control*
  • Long-Term Care
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / diagnosis
  • Myocardial Infarction / drug therapy*
  • Pravastatin / economics*
  • Pravastatin / therapeutic use
  • Quality of Life*
  • Secondary Prevention
  • Sensitivity and Specificity


  • Pravastatin