Abstract
Basic fibroblast growth factor (bFGF) is a potent mitogen for a number of different cell types. Its over-expression has been implicated in transformation and malignant progression. The use of bFGF to treat malignancy is therefore counterintuitive. However, recent studies have shown bFGF-induces cell death in some tumour types. This mini review will summarise the most recent findings on bFGF-induced cell death and discuss its potential mechanism of action.
MeSH terms
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Caspases / metabolism
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Cell Death / drug effects*
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Fibroblast Growth Factor 2 / metabolism
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Fibroblast Growth Factor 2 / pharmacology*
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G1 Phase / drug effects
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Humans
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Proto-Oncogene Proteins c-myc / genetics
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Proto-Oncogene Proteins c-myc / metabolism
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Receptors, Fibroblast Growth Factor / metabolism
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Tumor Suppressor Protein p53 / metabolism
Substances
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Proto-Oncogene Proteins c-bcl-2
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Proto-Oncogene Proteins c-myc
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Receptors, Fibroblast Growth Factor
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Tumor Suppressor Protein p53
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Fibroblast Growth Factor 2
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Caspases