Evolution and current use of the tuberculin test

Clin Infect Dis. 2002 Feb 1;34(3):365-70. doi: 10.1086/338149. Epub 2001 Dec 13.


Since it was first introduced in the late 1800s, the tuberculin test has undergone continual refinement in its formulation, standardization, and dosage, as well as its interpretation and indications for use. New guidelines have replaced universal screening with targeted testing and rigid definitions of positivity with individualized criteria formulated from a Bayesian approach. This review summarizes the evolution of the test and provides information to help gauge its predictive value.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / analysis*
  • Bacterial Proteins / genetics
  • Evolution, Molecular
  • HIV Infections
  • Humans
  • Predictive Value of Tests
  • Tuberculin Test / methods
  • Tuberculin Test / standards*


  • Bacterial Proteins
  • tuberculoprotein, Mycobacterium tuberculosis