Dopamine system stabilizers, aripiprazole, and the next generation of antipsychotics, part 1, "Goldilocks" actions at dopamine receptors

J Clin Psychiatry. 2001 Nov;62(11):841-2. doi: 10.4088/jcp.v62n1101.

Abstract

Dopamine system stabilizers are a potential new class of antipsychotic agents without motor side effects. All known effective antipsychotics act at D2 receptors. A novel concept for an antipsychotic without motor side effects is to stabilize these receptors rather than block them harshly.

MeSH terms

  • Antipsychotic Agents / pharmacokinetics
  • Antipsychotic Agents / pharmacology*
  • Aripiprazole
  • Binding Sites / drug effects
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism
  • Dopamine Agents / pharmacokinetics
  • Dopamine Agents / pharmacology*
  • Humans
  • Piperazines / pharmacokinetics
  • Piperazines / pharmacology*
  • Psychotic Disorders / drug therapy*
  • Quinolones / pharmacokinetics
  • Quinolones / pharmacology*
  • Receptors, Dopamine D2 / drug effects*
  • Receptors, Dopamine D2 / metabolism
  • Substantia Nigra / drug effects
  • Substantia Nigra / metabolism

Substances

  • Antipsychotic Agents
  • Dopamine Agents
  • Piperazines
  • Quinolones
  • Receptors, Dopamine D2
  • Aripiprazole