Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q

Science. 2002 Jan 4;295(5552):120-3. doi: 10.1126/science.1064653.

Abstract

The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by approximately 60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging*
  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Diet
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Fermentation
  • Forkhead Transcription Factors
  • Genes, Helminth
  • Helminth Proteins / genetics
  • Helminth Proteins / metabolism
  • Larva / growth & development
  • Larva / metabolism
  • Longevity*
  • Mitochondria / metabolism
  • Models, Biological
  • Mutation
  • Oxidation-Reduction
  • Oxygen Consumption
  • Phenotype
  • Reactive Oxygen Species / metabolism
  • Receptor, Insulin / genetics
  • Receptor, Insulin / metabolism
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Signal Transduction
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Ubiquinone / administration & dosage
  • Ubiquinone / metabolism*

Substances

  • CLK-1 protein, C elegans
  • Caenorhabditis elegans Proteins
  • DAF-12 protein, C elegans
  • Forkhead Transcription Factors
  • Helminth Proteins
  • Reactive Oxygen Species
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • daf-16 protein, C elegans
  • Ubiquinone
  • ubiquinone 8
  • DAF-2 protein, C elegans
  • Receptor, Insulin
  • ubiquinone 9