The dual association between lymphoma and autoimmunity

Blood Cells Mol Dis. Jul-Aug 2001;27(4):750-6. doi: 10.1006/bcmd.2001.0442.

Abstract

Autoimmune rheumatic diseases and lymphocytic malignancies are related and this association is bidirectional. Lymphomas occur more frequently in the course of autoimmune disease and autoimmune rheumatic manifestations occur in the course of lymphocytic malignancies. An increased incidence of malignant lymphocytic diseases is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, and autoimmune thyroid disease. Descriptions of lymphocytic malignancies among other autoimmune rheumatic disease have been published. In some patients, the malignant disease is diagnosed months or years before the appearance of the rheumatic disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigens, Neoplasm / immunology
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / epidemiology
  • Autoantibodies / analysis
  • Autoantibodies / immunology
  • Autoantigens / immunology
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / epidemiology
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology
  • Azathioprine / adverse effects
  • Cell Transformation, Neoplastic / chemically induced
  • Cell Transformation, Neoplastic / immunology
  • Cohort Studies
  • Comorbidity
  • Disease Susceptibility
  • Genetic Predisposition to Disease
  • HLA Antigens / genetics
  • Immunosuppressive Agents / adverse effects
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / epidemiology
  • Lymphoma / chemically induced
  • Lymphoma / epidemiology
  • Lymphoma / etiology*
  • Lymphoma / genetics
  • Lymphoma / immunology
  • Lymphoproliferative Disorders / chemically induced
  • Lymphoproliferative Disorders / epidemiology
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / immunology
  • Paraneoplastic Syndromes / etiology
  • Paraneoplastic Syndromes / immunology
  • Prospective Studies
  • Retrospective Studies
  • Risk
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / drug therapy
  • Sjogren's Syndrome / epidemiology
  • Vasculitis / complications
  • Vasculitis / epidemiology

Substances

  • Antigens, Neoplasm
  • Autoantibodies
  • Autoantigens
  • HLA Antigens
  • Immunosuppressive Agents
  • Azathioprine