Identification of a novel protease inhibitor gene that is highly expressed in the prostate

Biochem Biophys Res Commun. 2002 Jan 11;290(1):452-6. doi: 10.1006/bbrc.2001.6224.


A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosomes, Human, Pair 20
  • DNA, Complementary / metabolism
  • Elafin
  • Exons
  • Humans
  • Male
  • Molecular Sequence Data
  • Prostate / metabolism*
  • Protease Inhibitors / chemistry*
  • Protein Biosynthesis*
  • Protein Structure, Tertiary
  • Proteinase Inhibitory Proteins, Secretory
  • Proteins / chemistry
  • Proteins / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Tissue Distribution


  • DNA, Complementary
  • Elafin
  • PI3 protein, human
  • Protease Inhibitors
  • Proteinase Inhibitory Proteins, Secretory
  • Proteins
  • WFDC12 protein, human

Associated data

  • GENBANK/AY037803