Why is p53 acetylated?

Cell. 2001 Dec 28;107(7):815-8. doi: 10.1016/s0092-8674(01)00619-5.


Recent studies suggest that acetylation of the p53 tumor suppressor protein is not important for its DNA binding activity, as was previously thought. We discuss here a number of theories as to how this modification may serve to regulate the protein's functions.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Animals
  • Cell Cycle
  • Cell Death
  • DNA Repair
  • Genes, Tumor Suppressor
  • Humans
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*


  • Tumor Suppressor Protein p53