Conserved cues for axon and dendrite growth in the developing cortex

Neuron. 2002 Jan 3;33(1):2-4. doi: 10.1016/s0896-6273(01)00577-3.

Abstract

The cellular and molecular mechanisms that guide axonal and dendritic differentiation in the cerebral cortex are just beginning to be defined. Many of the molecular signals that guide axons also, and sometimes simultaneously, influence dendritic growth. Whitford et al. (2002 [this issue of Neuron]) demonstrate that in addition to their roles in axon guidance and cell migration cue, Slit proteins can also regulate dendritic growth.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cell Differentiation / physiology*
  • Cerebral Cortex / cytology
  • Cerebral Cortex / embryology*
  • Cerebral Cortex / metabolism
  • Chemotaxis / physiology*
  • Dendrites / metabolism*
  • Dendrites / ultrastructure
  • Growth Cones / metabolism*
  • Growth Cones / ultrastructure
  • Humans
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism
  • Semaphorin-3A*

Substances

  • Carrier Proteins
  • Nerve Tissue Proteins
  • Receptors, Immunologic
  • SEMA3A protein, human
  • SLIT1 protein, human
  • Sema3a protein, mouse
  • Semaphorin-3A
  • roundabout protein