Two successful pregnancies after conservative treatment of endometrial cancer and assisted reproduction

Fertil Steril. 2002 Jan;77(1):188-9. doi: 10.1016/s0015-0282(01)02937-5.


Objective: To report successful pregnancies after conservative management of FIGO grade I adenocarcinoma of the endometrium.

Design: Retrospective chart review.

Setting: University-based assisted reproduction and oncology units.

Patient(s): One patient who had two separate pregnancies.

Intervention(s): High-dose progestin (megestrol acetate) therapy for adenocarcinoma, followed by assisted reproduction with donor oocyte.

Main outcome measure(s): Histologic evaluation of endometrium after megestrol acetate and at completion of childbearing, and successful pregnancies and deliveries.

Result(s): The patient had complete resolution of adenocarcinoma with progestin therapy and successful delivery of two pregnancies after assisted reproduction.

Conclusion(s): Conservative management of International Federation of Gynecology and Obstetrics grade I adenocarcinoma of the endometrium allows preservation of childbearing.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adult
  • Delivery, Obstetric
  • Endometrial Neoplasms / drug therapy*
  • Endometrium / pathology
  • Female
  • Humans
  • Infant, Newborn
  • Megestrol Acetate / therapeutic use*
  • Pregnancy
  • Reproductive Techniques, Assisted*


  • Megestrol Acetate