Exploring the protein interactome using comprehensive two-hybrid projects

Trends Biotechnol. 2001 Oct;19(10 Suppl):S23-7. doi: 10.1016/S0167-7799(01)01790-5.


Large-scale two-hybrid projects were used in an approach to examine protein-protein interactions. Despite the various limitations of this approach, these projects revealed a wealth of novel interactions, and the protein interactome may be much larger than expected.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Computational Biology / methods*
  • Genomics / methods
  • Protein Interaction Mapping / methods*
  • Saccharomycetales / genetics
  • Software
  • Two-Hybrid System Techniques*