A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues

BMC Genet. 2001:2:22. doi: 10.1186/1471-2156-2-22. Epub 2001 Dec 20.


Background: Proximal chromosome 15q is implicated in neurodevelopmental disorders including Prader-Willi and Angelman syndromes, autistic disorder and developmental abnormalities resulting from chromosomal deletions or duplications. A subset of genes in this region are subject to genomic imprinting, the expression of the gene from only one parental allele.

Results: We have now identified the NDNL2 (also known as MAGE-G) gene within the 15q autistic disorder susceptibility region and have mapped its murine homolog to the region of conserved synteny near necdin (Ndn) on mouse Chr 7. NDNL2/MAGE-G is a member of a large gene family that includes the X-linked MAGE cluster, MAGED1 (NRAGE), MAGEL2 and NDN, where the latter two genes are implicated in Prader-Willi syndrome. We have now determined that NDNL2/Ndnl2 is widely expressed in mouse and human fetal and adult tissues, and that it is apparently not subject to genomic imprinting by the PWS/AS Imprinting Center.

Conclusion: Although NDNL2/MAGE-G in the broadly defined chromosome 15 autistic disorder susceptibility region, it is not likely to be pathogenic based on its wide expression pattern and lack of imprinted expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autistic Disorder / genetics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15*
  • Genetic Predisposition to Disease
  • Genomic Imprinting
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics
  • Nuclear Proteins / genetics
  • Protein Biosynthesis
  • Proteins / genetics*
  • RNA, Messenger / biosynthesis
  • Sequence Homology, Amino Acid
  • Synteny
  • Tissue Distribution
  • Transcription, Genetic


  • Intracellular Signaling Peptides and Proteins
  • NSMCE3 protein, human
  • Nerve Tissue Proteins
  • Nsmce3 protein, mouse
  • Nuclear Proteins
  • Proteins
  • RNA, Messenger
  • necdin

Associated data

  • GENBANK/AC016484
  • GENBANK/AF320911