Model organisms as a guide to mammalian aging

Dev Cell. 2002 Jan;2(1):9-19. doi: 10.1016/s1534-5807(01)00098-3.


Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast Saccharomyces cerevisiae and highlight general features of the regulation of aging that may have implications for mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Caenorhabditis elegans / physiology*
  • Mammals
  • Models, Animal
  • Saccharomyces cerevisiae / physiology*