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Review
. 2002 Jan;2(1):9-19.
doi: 10.1016/s1534-5807(01)00098-3.

Model Organisms as a Guide to Mammalian Aging

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Review

Model Organisms as a Guide to Mammalian Aging

Heidi A Tissenbaum et al. Dev Cell. .

Abstract

Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast Saccharomyces cerevisiae and highlight general features of the regulation of aging that may have implications for mammals.

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