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. 2001 Oct;132(4):959-62.
doi: 10.1023/a:1013663126973.

Proline-containing Dipeptide GVS-111 Retains Nootropic Activity After Oral Administration

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Proline-containing Dipeptide GVS-111 Retains Nootropic Activity After Oral Administration

R U Ostrovskaya et al. Bull Exp Biol Med. .

Abstract

Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.

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