Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration

Bull Exp Biol Med. 2001 Oct;132(4):959-62. doi: 10.1023/a:1013663126973.


Experiments on rats trained passive avoidance task showed that N-phenyl-acetyl-L-prolyl-glycyl ethyl ester, peptide analog of piracetam (GVS-111, Noopept) after oral administration retained antiamnesic activity previously observed after its parenteral administration. Effective doses were 0.5-10 mg/kg. Experiments on a specially-developed model of active avoidance (massive one-session learning schedule) showed that GVS-111 stimulated one-session learning after single administration, while after repeated administration it increased the number of successful learners among those animals who failed after initial training. In this respect, GVS-111 principally differs from its main metabolite cycloprolylglycine and standard nootropic piracetam.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Avoidance Learning
  • Dipeptides / administration & dosage*
  • Dipeptides / pharmacology*
  • Dose-Response Relationship, Drug
  • Learning / drug effects
  • Neuroprotective Agents / administration & dosage*
  • Neuroprotective Agents / pharmacology*
  • Nootropic Agents / administration & dosage*
  • Nootropic Agents / pharmacology*
  • Proline / chemistry*
  • Rats


  • Dipeptides
  • Neuroprotective Agents
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly
  • Proline