Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

Ann Neurol. 2002 Jan;51(1):133-6. doi: 10.1002/ana.10079.


We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain-Derived Neurotrophic Factor / genetics*
  • Cytochrome P-450 Enzyme System / genetics
  • Dopamine / genetics
  • Female
  • Genetic Predisposition to Disease
  • Homozygote
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Thiolester Hydrolases / genetics
  • Ubiquitin Thiolesterase


  • Brain-Derived Neurotrophic Factor
  • Cytochrome P-450 Enzyme System
  • Thiolester Hydrolases
  • Ubiquitin Thiolesterase
  • Dopamine