Objective: To find a simple, effective, with few side effect method of pre-cleaning intestine for surgical operation of abdominal malignancy.
Methods: Thirty-five patients of abdominal malignant tumor were divided into two groups randomly and treated with Dachengqi Granule (DCQG) and routine western management (including oral taking antibiotics and enema with soap solution) respectively. Serum level of nitric oxide (NO), tumor necrosis factor (TNF), intercellular adhesive molecule-1 (ICAM-1), and enteric function recovering of patients were observed before operation, and 1, 3 and 7 days after operation.
Results: Time of borborygmus recovering and gas discharging after operation in the DCQG group was earlier than that of the control group, P < 0.05. Serum NO level was raised in both groups after operation, and reaching peak level at 3rd day post-operationally, as compared with pre-operation, P < 0.05, the difference between the two groups was insignificant. Serum TNF level lowered in both groups, but more apparent in the DCQG group, the inter-group difference was significant at the first day of operation, P < 0.05. Serum ICAM-1 level in the DCQG group decreased at the day 3 after operation with significant difference in comparison with pre-operational level, P < 0.05, but in the control group, change of ICAM-1 before and after operation was insignificant. The mean ICAM-1 level of the DCQG group at the day 3 post-operationally was significantly lower than that of the control group, P < 0.05.
Conclusions: Compared with the routine management of western medicine, using DCQG for intestine pre-cleaning before operation could obviously lower the operation induced inflammatory reaction of tumor patients, reduce the secretion of inflammatory mediator, improve the recovery of enteric function and reduce the post-operational complication. Therefore, applying DCQG for pre-operational enteric preparing could provide a satisfactory effect in surgical operation of abdominal malignancy.