Dorsal pancreas agenesis in N-cadherin- deficient mice

Dev Biol. 2001 Oct 1;238(1):202-12. doi: 10.1006/dbio.2001.0405.


Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis
  • Cadherins / genetics*
  • Cadherins / physiology*
  • Cell Adhesion
  • Cell Differentiation
  • Endoderm / metabolism
  • Genotype
  • Heterozygote
  • Immunohistochemistry
  • In Situ Hybridization
  • In Situ Nick-End Labeling
  • Mesoderm / metabolism
  • Mice
  • Mice, Transgenic
  • Microscopy, Electron
  • Mutation
  • Pancreas / embryology
  • Pancreas / metabolism*
  • Time Factors
  • Tissue Distribution


  • Cadherins