A practical six-step synthesis of (S)-camptothecin

D L Comins; J M Nolan

doi:10.1021/ol0169271

A practical six-step synthesis of (S)-camptothecin

Org Lett. 2001 Dec 27;3(26):4255-7. doi: 10.1021/ol0169271.

Authors

D L Comins¹, J M Nolan

Affiliation

¹ Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA. daniel_comins@ncsu.edu

PMID: 11784191
DOI: 10.1021/ol0169271

Abstract

An asymmetric synthesis of (S)-camptothecin (1) has been accomplished in six steps starting from two commercially available heterocycles. [reaction: see text]

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / chemistry
Camptothecin / chemical synthesis*
Camptothecin / chemistry
Heterocyclic Compounds / chemistry

Substances

Antineoplastic Agents, Phytogenic
Heterocyclic Compounds
Camptothecin