Hyaluronan: polysaccharide chaos to protein organisation

Curr Opin Struct Biol. 2001 Oct;11(5):617-22. doi: 10.1016/s0959-440x(00)00256-6.

Abstract

Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan-protein interactions. Various studies on hyaluronan-binding proteins suggest there is considerable diversity in their mode of interaction with hyaluronan, which might result in many different bound conformations of the polysaccharide.

Publication types

  • Review

MeSH terms

  • Carbohydrate Conformation
  • Hyaluronan Receptors / chemistry*
  • Hyaluronic Acid / chemistry*
  • Macromolecular Substances
  • Models, Molecular
  • Polysaccharide-Lyases / chemistry
  • Protein Binding
  • Solutions
  • Thermodynamics

Substances

  • Hyaluronan Receptors
  • Macromolecular Substances
  • Solutions
  • Hyaluronic Acid
  • Polysaccharide-Lyases
  • hyaluronate lyase