Role of heparan sulfate in fibroblast growth factor signalling: a structural view

Curr Opin Struct Biol. 2001 Oct;11(5):629-34. doi: 10.1016/s0959-440x(00)00258-x.

Abstract

Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to different models for receptor dimerisation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Crystallography, X-Ray
  • Fibroblast Growth Factor 1 / chemistry
  • Fibroblast Growth Factors / chemistry*
  • Heparitin Sulfate / chemistry*
  • Macromolecular Substances
  • Models, Molecular
  • Molecular Structure
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor, Fibroblast Growth Factor, Type 2
  • Receptors, Fibroblast Growth Factor / chemistry
  • Signal Transduction

Substances

  • Macromolecular Substances
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factor 1
  • Fibroblast Growth Factors
  • Heparitin Sulfate
  • Receptor Protein-Tyrosine Kinases
  • Receptor, Fibroblast Growth Factor, Type 2