CA 125: the end of the beginning

Tumour Biol. Nov-Dec 2001;22(6):345-7. doi: 10.1159/000050637.


CA 125, a high-molecular-weight mucin, was first defined in 1981 by the monoclonal antibody OC125. Until recently, it has defied many attempts to purify it from a variety of sources, although many research groups have successfully raised antibodies that bind to CA 125. Nevertheless, CA 125 has demonstrated its considerable value as a marker in monitoring patients with ovarian cancer. This year, two research groups have succeeded in cloning the high-molecular-weight mucin CA 125. Their findings are summarized and the significance discussed in light of existing data from the human genome.

Publication types

  • Comment

MeSH terms

  • CA-125 Antigen / biosynthesis
  • CA-125 Antigen / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 19*
  • Cloning, Molecular
  • Female
  • Humans
  • Mucins / biosynthesis
  • Mucins / genetics
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / metabolism


  • CA-125 Antigen
  • Mucins