Peroxisome proliferator-activated receptor gamma and atherosclerosis

Curr Hypertens Rep. 2002 Feb;4(1):71-7. doi: 10.1007/s11906-002-0056-8.

Abstract

Within the past couple of years, peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear transcription factor expressed in vascular cells, has received growing interest in vascular biology and atherosclerosis research. Initially, PPARgamma was identified as a regulator of gene expression in lipid metabolism and adipogenesis, but recent data in monocyte/macrophages, endothelial cells, and vascular smooth muscle cells suggest that PPARgamma might have anti-inflammatory effects in atherogenesis. However, with growing insight, there is much controversy about potential anti- or proatherosclerotic effects. This review will focus on these aspects and discuss what PPARgamma activation in vascular cells could mean for atherogenesis and the development of atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arteriosclerosis / etiology*
  • Arteriosclerosis / metabolism
  • Gene Expression Regulation
  • Humans
  • Neovascularization, Pathologic
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction
  • Transcription Factors / metabolism*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Tumor Necrosis Factor-alpha