A closer look at proteolysis and MHC-class-II-restricted antigen presentation

Curr Opin Immunol. 2002 Feb;14(1):15-21. doi: 10.1016/s0952-7915(01)00293-x.


Antigen presentation by MHC class II molecules relies on the action of endocytic proteases, which are differentially expressed in antigen-presenting cells and are regulated by different components of the immune system. Endocytic enzymes process and convert exogenous antigens into peptidic determinants capable of interaction with MHC class II molecules. Chemical and genetic tools have recently been developed to study the role of lysosomal proteases in antigen presentation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Endocytosis / immunology
  • Endopeptidases / immunology*
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Mice
  • Phagosomes / immunology
  • Proteome


  • Histocompatibility Antigens Class II
  • Proteome
  • Endopeptidases