Roles of heat-shock proteins in antigen presentation and cross-presentation

Curr Opin Immunol. 2002 Feb;14(1):45-51. doi: 10.1016/s0952-7915(01)00297-7.


Heat-shock proteins chaperone antigenic peptides that are generated within cells. Such chaperoning is a part of the endogenous pathway of antigen presentation by MHC class I molecules. In addition, peptides that are chaperoned by heat-shock proteins, or are released by cell stress or death, are taken up by antigen-presenting cells and re-presented by their MHC molecules.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Heat-Shock Proteins / immunology*
  • Humans
  • Major Histocompatibility Complex / immunology
  • Molecular Chaperones / immunology


  • Heat-Shock Proteins
  • Molecular Chaperones