Toll-like receptors: key mediators of microbe detection

Curr Opin Immunol. 2002 Feb;14(1):103-10. doi: 10.1016/s0952-7915(01)00304-1.


Toll-like receptors are pattern-recognition receptors that have key roles in detecting microbes and initiating inflammatory responses. Recently, a host of new microbial products that activate specific Toll-like receptors have been defined, and additional components that mediate intracellular signaling have been identified. There has also been greater recognition of the importance of specific Toll-like receptors in host defense.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila Proteins*
  • Humans
  • Immunity, Innate*
  • Ligands
  • Membrane Glycoproteins / immunology*
  • Receptors, Cell Surface / immunology*
  • Signal Transduction / immunology*
  • Toll-Like Receptors


  • Drosophila Proteins
  • Ligands
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors