IL-1 and IL-18 receptors, and their extended family

Curr Opin Immunol. 2002 Feb;14(1):117-22. doi: 10.1016/s0952-7915(01)00306-5.


The cytokines IL-1 and IL-18 are key molecules in both the innate and the adaptive immune response. Recently, important insights have been gained into the regulation of their functions. Moreover, it has become apparent that they are members of a larger family of related receptors, some of which can also be shown to contribute to host defense.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity*
  • Interleukin-1 / immunology
  • Interleukin-18 / immunology
  • Interleukin-18 Receptor alpha Subunit
  • Receptors, Interleukin / immunology*
  • Receptors, Interleukin-1 / immunology*
  • Receptors, Interleukin-18
  • Signal Transduction / immunology


  • IL18R1 protein, human
  • Interleukin-1
  • Interleukin-18
  • Interleukin-18 Receptor alpha Subunit
  • Receptors, Interleukin
  • Receptors, Interleukin-1
  • Receptors, Interleukin-18