Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 12 (1), 30-5

Anchorage-dependent ERK Signaling--Mechanisms and Consequences

Affiliations
Review

Anchorage-dependent ERK Signaling--Mechanisms and Consequences

Alan K Howe et al. Curr Opin Genet Dev.

Abstract

Integrin-mediated adhesion to the extracellular matrix regulates the cellular response to mitogens. Anchorage-dependent growth factor activation of the extracellular signal-regulated kinase (ERK) is an intensely studied example of this regulation. Given the central role of ERK in mediating cell migration, division, and survival, it is also an extremely important example. Recent work has demonstrated that cell adhesion can regulate ERK signaling at several checkpoints and has begun to define the mechanism and consequences associated with anchorage-dependent effects on the ERK cascade.

Similar articles

See all similar articles

Cited by 54 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback