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, 12 (1), 30-5

Anchorage-dependent ERK Signaling--Mechanisms and Consequences


Anchorage-dependent ERK Signaling--Mechanisms and Consequences

Alan K Howe et al. Curr Opin Genet Dev.


Integrin-mediated adhesion to the extracellular matrix regulates the cellular response to mitogens. Anchorage-dependent growth factor activation of the extracellular signal-regulated kinase (ERK) is an intensely studied example of this regulation. Given the central role of ERK in mediating cell migration, division, and survival, it is also an extremely important example. Recent work has demonstrated that cell adhesion can regulate ERK signaling at several checkpoints and has begun to define the mechanism and consequences associated with anchorage-dependent effects on the ERK cascade.

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