Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

Curr Opin Genet Dev. 2002 Feb;12(1):47-52. doi: 10.1016/s0959-437x(01)00263-5.


Progression of resting quiescent G(0) cells into early G(1) and transition across the restriction point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor genes regulating these transitions are targeted during oncogenesis. Recent work has underscored the importance of the G(0) to early G(1) transition and metabolism to neoplastic cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Cyclins / metabolism
  • G1 Phase*
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Oncogenes / physiology*
  • Resting Phase, Cell Cycle
  • Retinoblastoma Protein / metabolism
  • Transcription, Genetic


  • Cyclins
  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases