Apolipoprotein E and diets: a case of gene-nutrient interaction?

Curr Opin Lipidol. 2002 Feb;13(1):25-32. doi: 10.1097/00041433-200202000-00005.


Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indications for such an interaction have been more common in studies employing a metabolic challenge. Studies directly designed to examine apolipoprotein E gene-nutrient interactions are needed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apolipoproteins E / genetics*
  • Apolipoproteins E / metabolism
  • Dietary Fats, Unsaturated / metabolism
  • Humans
  • Lipoproteins / blood
  • Lipoproteins / metabolism*
  • Nutritional Physiological Phenomena / physiology*
  • Polymorphism, Genetic*
  • Postprandial Period / physiology


  • Apolipoproteins E
  • Dietary Fats, Unsaturated
  • Lipoproteins