Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 14 (1), 10-8

Comprehensive Genotypic Analysis of Leukemia: Clinical and Therapeutic Implications

Affiliations
Review

Comprehensive Genotypic Analysis of Leukemia: Clinical and Therapeutic Implications

Louise Kelly et al. Curr Opin Oncol.

Abstract

Over the past several years, the application of a spectrum of cytogenetic and molecular diagnostic techniques has dramatically improved our understanding of the pathophysiology of leukemia. These techniques include chromosomal translocations visualized by G-banding techniques, fluorescence in-situ hybridization, spectral karyotyping, comparative genomic hybridization, loss of heterozygosity analysis, and characterization of point mutations by DNA sequence analysis. We will review the application of these techniques, update novel findings utilizing these techniques over the past year as they apply to specific leukemias, and review the clinical and therapeutic implications of these findings.

Similar articles

See all similar articles

Cited by 6 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback