Linkage analysis of Genetic Analysis Workshop 12 simulated data based on affected individuals only

Genet Epidemiol. 2001:21 Suppl 1:S510-5. doi: 10.1002/gepi.2001.21.s1.s510.

Abstract

A variety of allele-sharing methods was used to assess linkage to disease for a whole-genome screen in each of ten replicates from the Genetic Analysis Workshop 12 simulated data. Analysis of each replicate produced many false positive results in addition to a few "true" positives. Conditioning on the strongest initial linkage and reanalyzing using a variety of conditional methods did not improve the power for detection or help discriminate between true and false positive signals.

MeSH terms

  • Alleles
  • Chromosome Mapping / statistics & numerical data*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Lod Score
  • Mathematical Computing
  • Models, Genetic*
  • Phenotype
  • Software