Maximum Identity Length Contrast: A Powerful Method for Susceptibility Gene Detection in Isolated Populations

Genet Epidemiol. 2001;21 Suppl 1:S560-4. doi: 10.1002/gepi.2001.21.s1.s560.


We report the results of our analysis of the Genetic Analysis Workshop 12 simulated data set. Focusing on the isolated populations, we compare the efficiency of a new method, the maximum identity length contrast statistic (MILC) with the maximum likelihood score (MLS) in a genome screen strategy. MILC is a method based on the contrast of haplotype identity between transmitted and nontransmitted haplotypes in trios. It uses information on linkage and association. We found that MILC allows the detection of a risk factor corresponding to candidate gene 1 where the MLS fails, though the same population replicates were used. Interestingly, the association between this risk factor and the disease could not have been detected with the TDT at a genome-wide level.

MeSH terms

  • Chromosome Mapping / statistics & numerical data
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genetics, Population*
  • Haplotypes / genetics*
  • Humans
  • Linkage Disequilibrium
  • Maximum Allowable Concentration
  • Models, Genetic*
  • Phenotype