On the detection of linkage in multiple data sets: a comparison of various statistical approaches

P Van Eerdewegh; M Dowd; J Dupuis; K Falls; B Hayward; S L Santangelo

doi:10.1002/gepi.2001.21.s1.s67

On the detection of linkage in multiple data sets: a comparison of various statistical approaches

Genet Epidemiol. 2001:21 Suppl 1:S67-72. doi: 10.1002/gepi.2001.21.s1.s67.

Authors

P Van Eerdewegh¹, M Dowd, J Dupuis, K Falls, B Hayward, S L Santangelo

Affiliation

¹ Genome Therapeutics Corporation, 100 Beaver Street, Waltham, MA 02453, USA.

PMID: 11793760
DOI: 10.1002/gepi.2001.21.s1.s67

Abstract

We contrast the pooling of multiple data sets with the compound HLOD (HLOD-C) and the posterior probability of linkage (PPL), two approaches that have been shown to have more power in the presence of genetic heterogeneity. We also propose and evaluate several multipoint extensions.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Asthma / epidemiology
Asthma / genetics*
Child
Chromosome Mapping / statistics & numerical data*
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 6
Female
Genetic Heterogeneity
Genetics, Population
Humans
Likelihood Functions
Male
Models, Genetic
Probability
Statistics, Nonparametric

Abstract

Publication types

MeSH terms

Grants and funding