Detecting genotype x age interaction

Genet Epidemiol. 2001;21 Suppl 1:S819-24. doi: 10.1002/gepi.2001.21.s1.s819.


This paper explores several extensions to the variance component method, which incorporate genotype x age interaction effects. We evaluate the performance of these methods for detecting genotype x age interaction in quantitative genetic analyses of a quantitative trait (Q4), contrasting this with false positive detection rates obtained from a phenotype influenced by the same genes but without genotype x age interaction effects (Q3). We then assess the impact on linkage power and false positive rate of allowing a QTL-specific genotype x age interaction in linkage analysis of these same traits.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Alleles
  • Analysis of Variance
  • Chromosome Mapping / statistics & numerical data
  • Chromosomes, Human, Pair 17
  • Chromosomes, Human, Pair 9
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype*
  • Humans
  • Lod Score
  • Male
  • Middle Aged
  • Models, Genetic*
  • Quantitative Trait, Heritable