Sexual dysfunction secondary to gemfibrozil

Pharmacotherapy. 2002 Jan;22(1):123-5. doi: 10.1592/phco.


Hypertriglyceridemia is a well-recognized complication of protease inhibitor therapy, specifically ritonavir. Fibrate derivatives are recommended as first-line therapy for isolated triglyceride elevations, and gemfibrozil has been successful for managing protease inhibitor-induced lipid changes. A 35-year-old man experienced sexual dysfunction 3 weeks after starting gemfibrozil. The temporal relationship and improvement in sexual function after the drug was discontinued suggest that gemfibrozil may have been responsible for his sexual dysfunction.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Gemfibrozil / adverse effects*
  • Gemfibrozil / therapeutic use
  • HIV Protease Inhibitors / adverse effects
  • Humans
  • Hypertriglyceridemia / chemically induced
  • Hypertriglyceridemia / drug therapy*
  • Hypolipidemic Agents / adverse effects*
  • Hypolipidemic Agents / therapeutic use
  • Male
  • Penile Erection / drug effects
  • Ritonavir / adverse effects
  • Sexual Dysfunction, Physiological / chemically induced*


  • HIV Protease Inhibitors
  • Hypolipidemic Agents
  • Ritonavir
  • Gemfibrozil