Study on PDGF receptor beta pathway in glomerular formation in neonate mice

Ann N Y Acad Sci. 2001 Dec:947:303-5. doi: 10.1111/j.1749-6632.2001.tb03951.x.

Abstract

The assembly of vascular endothelial cells (ECs) and smooth muscle cells is a critical event in the development of the cardiovascular system. Although the role of ECs in this event has been studied intensively, the cross-talk between the two cell components remains poorly understood. In this study, we blocked platelet-derived growth factor receptor (PDGFR) pathways in mice by antagonistic rat monoclonal antibody APB5 against murine PDGFR-beta and examined glomerular capillary formation.

MeSH terms

  • Aging
  • Animals
  • Animals, Newborn
  • Antibodies, Monoclonal / pharmacology
  • Endothelium, Vascular / physiopathology
  • Kidney Glomerulus / growth & development*
  • Mice
  • Rats
  • Receptor Cross-Talk
  • Receptor, Platelet-Derived Growth Factor beta / antagonists & inhibitors
  • Receptor, Platelet-Derived Growth Factor beta / physiology*

Substances

  • Antibodies, Monoclonal
  • Receptor, Platelet-Derived Growth Factor beta