The effect of high doses of folic acid on the overexpression of ornithine decarboxylase and S-adenosylmethionine content in human colon adenomatous polyps

Ann N Y Acad Sci. 2001 Dec;952:175-6. doi: 10.1111/j.1749-6632.2001.tb02739.x.

Abstract

It was shown that the 3-month supplementation of patients having colon polyps with folic acid (5 mg/day) led to a 35% decrease in abnormally high ornithine decarboxylase activity in polyps that was accompanied by a 43% increase of S-adenosylmethionine content in polyps.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adenomatous Polyps / enzymology
  • Adenomatous Polyps / metabolism*
  • Colonic Polyps / enzymology
  • Colonic Polyps / metabolism*
  • Disease Progression
  • Double-Blind Method
  • Enzyme Induction / drug effects
  • Female
  • Folic Acid / administration & dosage
  • Folic Acid / pharmacology*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Male
  • Neoplasm Proteins / biosynthesis*
  • Neoplasm Proteins / genetics
  • Ornithine Decarboxylase / biosynthesis*
  • Ornithine Decarboxylase / genetics
  • S-Adenosylmethionine / metabolism*

Substances

  • Neoplasm Proteins
  • S-Adenosylmethionine
  • Folic Acid
  • Ornithine Decarboxylase