Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls

Mult Scler. 2001 Dec;7(6):371-4. doi: 10.1177/135245850100700605.


Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies. However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Bacterial / analysis
  • Cerebrospinal Fluid / microbiology*
  • Chlamydophila pneumoniae / genetics
  • Chlamydophila pneumoniae / immunology
  • Chlamydophila pneumoniae / isolation & purification*
  • DNA, Bacterial / analysis
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / microbiology*
  • Nervous System Diseases / cerebrospinal fluid*
  • Nervous System Diseases / microbiology*


  • Antibodies, Bacterial
  • DNA, Bacterial