"Burnout" began to be identified in the mid-1970s in the substance user treatment field with the meaning being that one's "fuel" to continue such work was essentially exhausted. "Burnout" is mostly manifest by emotional exhaustion and sometimes by various physical and psychiatric symptoms. In substance user treatment staff there is more "burnout" with more work pressure, unclear work policies, and decreased coping ability, with some "burnout" protection from peer and supervisor support. "Burnout" adversely effects substance user treatment and other human service interventions, with increased absenteeism and job turnover, and it appears to be helped with a variety of methods, including diversity of supports and interests. A case study of the author's substance user treatment and administrative work from the perspective of "burnout" considerations is included.