Cell adhesion molecules and adhesion abnormalities in prostate cancer

Crit Rev Oncol Hematol. 2002 Jan;41(1):11-28. doi: 10.1016/s1040-8428(01)00171-8.


Prostate cancer, the leading male cancer in Western countries, has accelerated in its incidence in the past decade. Patients with prostate cancer frequently have a poor prognosis as a result of local or distant spread of cancer. This review summarises some of the recent progress made in understanding the biology of cancer metastasis with a special emphasis on the role of cell adhesion molecules and adhesion abnormalities. The molecular and cellular function of cell adhesion molecules, their role in cancer and cancer progression, the clinical impact of these molecules, and therapeutic considerations are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / metabolism*
  • Cell Differentiation / physiology
  • Disease Progression
  • Humans
  • Male
  • Neoplasm Invasiveness
  • Prostatic Neoplasms / metabolism*
  • Prostatic Neoplasms / pathology


  • Cell Adhesion Molecules